Hi. It sounds to me like you may still have remnants of the infection(s). Here's what I would do:
Make a Macrium image of your OS drive, then also image your data drive. Use the Macrium Rescue media to boot your system and make the images. Save the images to a new, clean drive.
Put the permission(s) back, which you changed.
Run the following programs in this order:
TDSSKiller (check all boxes and let it reboot so it can scan properly)
RKILL (again, because everything RKILL does is undone by a reboot)
ADWCleaner (scan, then clean; it will reboot as well)
Malwarebytes Antimalware full custom scan of all drives
I would then do a repair install using an in-place upgrade, as previously suggested by Kbird. Select to keep apps and files.
Repair Install Windows 10 with an In-place Upgrade - Windows 10 Forums
If all is successful, delete the images you first made, and make new ones of the repaired system and data.
p.s. Everything I have suggested here is free.