Cannot pin progs to toolbar since last update

Win10 has just updated and I now cannot access my old desktop profile.
In addition, all my regular programs that were pinned to the toolbar have disappeared as well as their listing in 'All Apps' unless they are MS progs. So Mozilla Thunderbird and Firefox are not there, I started them from the program folders and clicked to 'pin to toolbar' but when I close them they do not stay pinned.
When I try to click into This PC\Desktop an error box appears saying:-

Location is not available
C:\Users\Administrator\Desktop is not available
Access is denied

Any help would be gratefully received.
Paulbear

Can you access desktop in Safe Mode using Admin logon ? If you can, you have a corrupted profile. Create a new User and try to log on with that one.