After setting the base resolution to 125%, the screen icons seemed unaffected--until the system is rebooted. At this point, icons are reset to maximum size (only eight fit on the screen). Once icons are manually resized, (Ctrl-Scroll), they're scattered all over the screen. Set "auto-position" and they return to their correct place (left border of the primary screen). Reboot and these changes did not persist. I assume that the system thinks I'm blind.

Frankly, I think the system is not shutting down correctly (completely?) and not writing these changes to the registry until the last minute and thus not persisted.

Running a dual-monitor Lenovo Thinkpad W510.