The manufacturer is taking advantage of the fact that this is an external hard drive, with an assumption that it will only be used for storage and not booting. However, this creates another set of compatibility problems, where programs that rely on 512-byte sector sizes may not work correctly:
Partitioning tools that do not support 4Kn drives will not function correctly with this drive.
Some database programs use direct disk I/O for performance and data integrity. These programs will not function correctly if they are not designed to handle 4K sectors.