USB Mouse and Keyboard intermittently not responding; Windows 10

Over the last few months (actually TBH the mouse started near the beginning of the year but it's been most notable during the last few months), both mouse and keyboard (specifically Razer Naga Hex v2 and Blackwidow Ultimate) have been intermittently failing to respond, albeit only partially. I've mostly noticed the issues with Skyrim, albeit both have suffered outside of the game. The issues are:

• Mouse: Randomly turns off the laser for at least several seconds at a time; sometimes unplugging and switching USB ports can help, but it is no guarantee. I am not using the keyboard's passthrough for this (if I use that port, it's for a game controller). Suffice to say, it is maddening when I suddenly have to pause my game and either wait or unplug/replug the mouse to be able to aim in the middle of combat.
• Keyboard: Mostly when I load Skyrim the letters will just stop responding until I quit and reload (which thankfully the Escape key and similar will still work), as if the game isn't initializing or linking into the driver properly. A few times this has carried over into everything in Windows 10, requiring in some cases a reboot but in others an outright uninstall and reinstall of a driver.

What I'm not sure of is if this could be a hardware issue (e.g. motherboard is dying, not sure what it is but can look it up if needed, albeit might take a while), or if I just need to reinstall or repair more drivers than I have so far. Is there a simple(ish) way to reinstall all the USB related drivers at once via an app (or even a USB thumbnail boot), instead of hunting through the Device Manager taking everything out one at a time and risking losing mouse and keyboard functionality till I hard reboot? I've managed to get a bit out of the loop with the best technical tools these last several years (basically since Windows 8 came out).

Something that may or may not be related is I have an SSD that started having issues while performing large-scale operations where it would just stop responding until I unplugged and replugged it, and eventually it just stopped responding altogether. However, it might be the device itself as the plug was kinda misaligned when it arrived and a pain in the derriere to get plugged in, and I've been in contact with the Amazon seller about sending it back for repairs as it could amount to the port essentially being broken.

So, update: I tried uninstalling various USB, mouse, and HID drivers from the Device Manager list, and while it seemed to help at first, the problem kept coming back, and now it's gotten worse. However, I've also identified a key feature of what triggers the problem: it triggers if I lift my mouse too high up so that the laser is not in contact with the mousepad any more, that's when the mouse seems to die for several seconds plus (it's extremely difficult, but possible, to lift it enough that it won't track but is still "connected" enough for me to recenter my mouse on the pad without a problem, but most times when I try to do it while gaming I'm too high above the sweet spot and have to wait for it to reset). Could it be my mouse that's dying?

Also, I did eventually look up my motherboard (in my specs now) and downloaded what was on the Asus website ( a USB driver, a set of apps including a couple that are for USB, an unrelated sound driver that I went ahead and installed, and finally a BIOS flash that I haven't gotten around to doing yet), but they didn't really seem to help (in fact, I ended up uninstalling one of the apps, a power management one, because it was giving me errors).

Any suggestions?