I just bought a new PC and installed W10 (previously was using W7) and when i plugged my headphones to front jack i did not have any sound at all. I googled for some time to find a solution and found that i have to check "Disable front panel jack detection" and i got the sound, BUT the sound was only in one side. When i was testing in Realtek HD Audio Manager it also played sound only in one side.

Headphones work fine so it probably is Windows glitch.
P.S. also tried to uninstall & reinstall drivers for Realtek HD Audio, didnt help.