Hope this may be of help to someone.

The following file/driver enabled me to run a 2480 scanner [paid 3 for at a car-boot] in windows 10 64bit

Epson Perfection 24803.0u

It is Version 3.0u

Make sure you remove all previous drivers for the scanner, then uninstall device from device manger.

Switch off the scanner + remove power source and USB lead.

Download and run the installer. After installation connect and turn on power then connect USB.

You should be good to go, but note previous "Smart Panel" software will not work You need to use the utility which is included with the driver or download and run the Vista 64bit "Epson Copy Utility.